منابع مشابه
Biosynthesis of penicillins; new crystalline biosynthetic penicillins.
Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is utilized by the mold in penicillin formation. To provide proof of the incorporation of various acyl groups into the penicillin molecule and to be able to determine the chemical characteristics and biological properties of the various penicillins, isolation and crystalliz...
متن کاملBiosynthesis of penicillins; utilization of deuterophenylacetyl-N15-dl-valine in penicillin biosynthesis.
In Paper I in this series (2) the stimulation of penicillin production by certain compounds containing the phenylacetyl group was reported. It was realized that a stimulation of yield of this biological product following addition of a given substance to the medium may result from any one of several possible metabolic mechanisms. The stimulating substance may act as a vitamin or growth promoter,...
متن کاملTissue Distribution of Penicillins.
WHILE it is of obvious importance to determine the antibacterial activity of a penicillin in the blood it is perhaps of greater importance to know what concentrations are present in the extravascular fluids. In view of the current interest in protein binding and its influence on activity it is also of importance to determine in what way binding influences distribution throughout the body. Usual...
متن کاملToxicity of the Penicillins.
THE absence of direct toxicity is one of the most remarkable properties of the penicillin molecule; that is to say, the penicillin molecule as we know it and as we should use it. If you try hard enough, you can make it toxic by altering it or abusing it, as I shall try to show later. With this reservation, one can say that penicillin G and the main therapeutic derivatives of 6-aminopenicillanic...
متن کاملPenicillins and cephalosporins.
Resemblances and differences between the penicillins (I) and cephalosporins (II) are considered from a chemical and biochemical point of view.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1948
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)57194-5